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Mode of Action (MoA)
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binds and sequesters CBASS signalling molecules (3′,3′-cGAMP, c-di-AMP, 3′,3′-c-di-UMP, 3′,3′-cUA and 3′,3′-cUG). Triggers the Panoptes defence system (DOI: 10.1038/s41586-025-09557-z) by binding 2′,3′-c-di-AMP, a signalling molecule synthesised by the defence system to keep it inactive.
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Evidence
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Genetic deletion of acb2 (deletion mutation phenotypic evidence, ECO_0001038) from the phage genome results in a loss of viral infectivity. Acb2 binding to the signaling molecules is supported by isothermal titration calorimetry evidence (ECO_0001825) and X-ray crystallography evidence (ECO_0005670).
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MoA Category
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degrades or sequesters molecules utilised by host defence systems
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Pseudomonas aeruginosa type II CBASS system
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Relevant publication(s)
DOI
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10.1016/j.cell.2022.12.041
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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8H2X_A
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Genome(s) encoding the protein
Protein Source
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Pseudomonas phage PaMx33
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Defence system(s) inhibited by the protein
Defences
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CBASS
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