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Mode of Action (MoA)
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replaces Cas5 (shares sequence similarity to Cas proteins) in a defective Cascade interference complex that fails to engage target DNA.
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Evidence
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Ectopic expression of AcrIB3 in L. seeligeri LS1 (ECO_0001038) blocked Cas3-mediated degradation of a target plasmid. Expression of AcrIB3 blocks CRISPR interference. AcrIB3 co-purified with the Cascade complex (Cas6–3×Flag), indicating it integrates into the complex (ECO_0000085).
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Listeria seeligeri type I-B CRISPR-Cas
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Relevant publication(s)
DOI
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10.1038/s41586-024-07923-x
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE and prophages in Listeria genomes
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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