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Mode of Action (MoA)
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None
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Evidence
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DMS3m phage was genetically engineered to carry the acrIC1 gene. This phage was then used to infect PAO1IC, a strain expressing the PaLML1 Type I-C system and a phage-targeting crRNA. The engineered phage produced plaques on PAO1IC at levels comparable to a control strain lacking CRISPR targeting. In CRISPRi assays, it did not relieve transcriptional repression, indicating that Cascade still binds DNA.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Moraxella bovoculi type I-C CRISPR-Cas
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Relevant publication(s)
DOI
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10.1126/science.aau5174,
10.1093/nar/gkab006
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Moraxella bovoculi
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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