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Mode of Action (MoA)
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AlphaFold 3 predicts a direct interaction between Cas7c (https://www.ncbi.nlm.nih.gov/protein/UEM35122.1) and AcrIC10 (ipTM = 0.75, pTM = 0.78).
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Evidence
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Ectopic expression (ECO_0000017) of AcrIC10 in P. aeruginosa strains expressing type I-C CRISPR-Cas system restored plating efficiency of CRISPR-sensitive phages JBD8 and DMS3m. Binding it supported by computational structure modeling evidence (ECO_0006368).
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MoA Category
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binds and inhibits host defence system (putative)
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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P. aeruginosa strains LL77 type I-C CRISPR-Cas system
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Relevant publication(s)
DOI
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10.1038/s41467-020-17652-0
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Xanthomonas translucens
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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