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Mode of Action (MoA)
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None
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Evidence
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The DMS3m phage expressing acrIC6 showed only partial restoration of infectivity on PAO1IC (EOP ≈ 0.01), suggesting weak inhibition of the Type I-C system. It also did not relieve repression in CRISPRi assays, leaving its mechanism unclear. AcrIC6 had marginal activity against the Type I-E system as well.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Pseudomonas aeruginosa type I-C CRISPR-Cas system
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Relevant publication(s)
DOI
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10.1093/nar/gkab006
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Pseudomonas phragmitis
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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