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Mode of Action (MoA)
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None
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Evidence
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Three homologs of acrIC7 (from P. stutzeri, P. citronellolis, and P. aeruginosa) were expressed from DMS3m and tested on PAO1IC and a Type I-E strain. AcrIC7Pst and AcrIC7Pci blocked both Type I-C and I-E systems (EOP ≈ 1 in both). AcrIC7Pae only blocked I-E, not I-C. CRISPRi confirmed that all three variants that inhibited systems also blocked DNA binding.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Pseudomonas aeruginosa type I-C CRISPR-Cas system
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Relevant publication(s)
DOI
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10.1093/nar/gkab006
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Pseudomonas stutzeri
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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