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Mode of Action (MoA)
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mimics the shape and charge distribution of double-stranded DNA (dsDNA), effectively occupying the site where the PAM interacts with the Cascade.
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Evidence
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Ectopic expression (ECO_0000017) of AcrIC9 in P. aeruginosa strains expressing type I-C CRISPR-Cas system restored plating efficiency of CRISPR-sensitive phages JBD8 and DMS3m.
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Pseudomonas aeruginosa strains LL77 type I-C CRISPR-Cas system
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Relevant publication(s)
DOI
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10.1038/s41467-020-17652-0,
/10.1016/j.molcel.2023.12.034
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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8G9T_A
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Genome(s) encoding the protein
Protein Source
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Rhodobacter phage RcNL1
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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