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Mode of Action (MoA)
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None
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Evidence
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AcrIE6 was validated via ectopic expression (ECO_0000017) in P. aeruginosa with type I-E CRISPR-Cas targeting phage JBD8. Phage plaque formation indicated that AcrIE6 effectively inhibited CRISPR immunity.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Pseudomonas aeruginosa SMC4386 type I-E CRISPR-Cas
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Relevant publication(s)
DOI
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10.1126/science.aau5174
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Pseudomonas aeruginosa SMC4386
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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