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Mode of Action (MoA)
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None
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Evidence
|
AcrIE7 showed activity against type I-E CRISPR-Cas when ectopically expressed in P. aeruginosa (ECO_0000017). Phage replication assays using JBD8 confirmed successful immune evasion.
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MoA Category
|
unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
|
Pseudomonas aeruginosa SMC4386 type I-E CRISPR-Cas
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Relevant publication(s)
DOI
|
10.1126/science.aau5174
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Other components of the anti-defence system
Multicomponent System
|
-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
|
MGE in Pseudomonas aeruginosa SMC4386
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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