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Mode of Action (MoA)
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None
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Evidence
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Ectopic expression (ECO_0000017) of acrIIa12 in Listeria monocytogenes inhibits Cas9-mediated targeting measured in a plaque formation assay. It inhibits CRISPRi, likely acting upstream of DNA targeting.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Listeria monocytogenes type II-A CRISPR-Cas
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Relevant publication(s)
DOI
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10.1016/j.chom.2020.04.001
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Listeria monocytogenes prophage φA006
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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