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Mode of Action (MoA)
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None
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Evidence
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Ectopic expression (ECO_0000017) of AcrIIA17 in a P. aeruginosa strain with a heterologous SpyCas9 CRISPR system restores replication of sensitive phage. AcrIIA16's expression inhibit CRISPR Interference, suggesting inhibiting of SpyCas9 at the step of target DNA binding or at an upstream stage. Co-immunoprecipitation (ECO_0005644) showed binding to Cas9.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Streptococcus pyogenes type II-A CRISPR-Cas
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Relevant publication(s)
DOI
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10.1038/s41564-020-0692-2
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Enterococcus faecalis
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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