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Mode of Action (MoA)
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None
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Evidence
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Cloned from a Streptococcus mobile genetic element, AcrIIA27 provided complete rescue in E. coli expressing SpyCas9 or St3Cas9 in plasmid interference assays (ECO_0000017). In vitro cleavage assays confirmed inhibition only when Acr was added prior to DNA, suggesting inhibition of binding.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Streptococcus thermophilus and Streptococcus pyogenes type II-A CRISPR-Cas
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Relevant publication(s)
DOI
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10.1093/nar/gkac099
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Streptococcus pyogenes K23866
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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