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Mode of Action (MoA)
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binds Cas9, inhibiting its activity.
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Evidence
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Ectopic expression (ECO_0000017) of AcrIIA5 increased the plating efficiency of phage D5842 that is normally targeted by active type II-A CRISPR–Cas systems. Binding to Cas9-DNA complex is supported by Electrophoretic Mobility Shift Assays (ECO_0000096).
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Streptococcus thermophilus type II-A CRISPR-Cas
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Relevant publication(s)
DOI
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10.1038/s41564-017-0004-7,
10.1016/j.celrep.2019.10.078
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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6LKF
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Genome(s) encoding the protein
Protein Source
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Streptococcus phage D4276
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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