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Mode of Action (MoA)
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binds Cas9 through interactions with the positively charged bridge helix, thereby preventing crRNA loading.
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Evidence
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Binding is supported by x-ray crystallography evidence (ECO_0005670).
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Neisseria meningitidis type II-C CRISPR-Cas
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Relevant publication(s)
DOI
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10.1016/j.cell.2016.11.017
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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6J9M_B
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Genome(s) encoding the protein
Protein Source
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MGE in Neisseria meningitidis
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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