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Mode of Action (MoA)
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inhibits Cas12a via acetylation, similar to its remote structural homolog, AcrVA5.
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Evidence
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In vitro assay showed ability to inhibit DNA cleavage by Cas12a (ECO_0000183).
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MoA Category
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adds a post-translational modification and deactivates bacterial defence
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Lachnospiraceae bacterium type V-A CRISPR-Cas
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Relevant publication(s)
DOI
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10.1038/s41467-024-45068-7
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Bacteroidota phage (IMG_VR genome, ID: Ga0247610_10000168)
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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View homologs from eukaryotic dsDNA viruses
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