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Mode of Action (MoA)
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binds to the Riemerella anatipestifer Cas13b.
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Evidence
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Ectopic expression (ECO_0000017) of AcrVIB1 abolishes Cas13b interference in bacterial plasmid transformation and phage infection assays. Cell-free TXTL assays show potent inhibition of Cas13b RNA cleavage activity (ECO_0006064). Timing experiments indicate inhibition occurs upstream of ribonucleoprotein complex formation (AcrVIB1 is most effective when added before RNP (Cas13b:gRNA) complex formation).
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Prevotella buccae type VI-B CRISPR-Cas
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Relevant publication(s)
DOI
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10.1016/j.molcel.2022.05.003,
10.1016/j.molcel.2025.01.020
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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MGE in Riemerella anatipestifer
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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