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Mode of Action (MoA)
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inhibit a broad range of nucleic-acid-targeting defense systems, but MoA is unknown
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Evidence
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Ectopic expression (ECO_0000017) of Bdi1 in Pseudomonas aeruginosa inhibits Zorya type I, RADAR, Hypnos, and Druantia type I antiphage defense systems in plaque formation and culture collapse assays. Site-directed mutagenesis of residues D14A, L33E, and W54A abolishes Bdi1-mediated inhibition of Zorya type I (ECO_0001038).
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Druantia type I;Zorya type I;Hypnos;RADAR
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Relevant publication(s)
DOI
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10.1016/j.chom.2025.06.010
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Pseudomonas phage Nemo
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Defence system(s) inhibited by the protein
Defences
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Druantia,
Zorya,
Hypnos,
RADAR
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