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Mode of Action (MoA)
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recognises the sequence 5'-GATC-3' and methylates adenine, preventing recognition of phage DNA by the MboI restriction nuclease. Triggers Dazbog and retron Sen2 defences.
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Evidence
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Ectopic expression of the T4 dam⁺ gene in E. coli dam⁻ cells methylates plasmid DNA at GATC sites, rendering it resistant to MboI digestion (ECO_0000017).
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MoA Category
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modifies phage molecules to avoid recognition
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli RM
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Relevant publication(s)
DOI
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10.1016/0378-1119(83)90098-7
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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1YFJ_A
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Genome(s) encoding the protein
Protein Source
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Enterobacteria phage T4
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Defence system(s) inhibited by the protein
Defences
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RM
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View homologs from eukaryotic dsDNA viruses
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