{
  "id": "darb",
  "name": "DarB",
  "moa": "contains a methyltransferase domain, likely modifying phage. ",
  "moa_category": "modifies phage molecules to avoid recognition",
  "evidence": "Genetic deletions (deletion mutation phenotypic evidence, ECO_0001038) result in high sensitivity to RM systems, while ectopic expression (ECO_0000017) restores plating efficiency. ",
  "defence_subtype": "Escherichia coli type I RM",
  "doi": "10.1016/0042-6822(87)90324-2;10.1111/mmi.13705",
  "multicomponent": "dara;hdf;ddrb;ddra;ulx",
  "pdb": null,
  "structure_type": "AlphaFold 3",
  "protein_source_name": "Enterobacteria phage P1",
  "protein_source_link": "https://www.ncbi.nlm.nih.gov/nuccore/NC_005856.1",
  "defences": [
    {
      "name": "RM",
      "link": "https://defensefinder.mdmlab.fr/wiki/defense-systems/rm"
    }
  ],
  "pfam_annotations": [
    {
      "name": "Eco57I",
      "accession": "PF07669.17",
      "length": 171,
      "evalue": 2.3e-09,
      "hmm_from": 69,
      "hmm_to": 156,
      "ali_from": 166,
      "ali_to": 244,
      "env_from": 127,
      "env_to": 251
    },
    {
      "name": "Helicase_C",
      "accession": "PF00271.37",
      "length": 110,
      "evalue": 3.6e-08,
      "hmm_from": 49,
      "hmm_to": 110,
      "ali_from": 1455,
      "ali_to": 1517,
      "env_from": 1434,
      "env_to": 1517
    },
    {
      "name": "N6_Mtase",
      "accession": "PF02384.22",
      "length": 311,
      "evalue": 1.5e-09,
      "hmm_from": 93,
      "hmm_to": 248,
      "ali_from": 145,
      "ali_to": 290,
      "env_from": 66,
      "env_to": 296
    }
  ]
}