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Mode of Action (MoA)
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inserts the 7-deazaguanine base into phage genomic DNA, with 2′-deoxy-7-deazaguanine modifications protecting phage DNA from host restriction enzymes.
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Evidence
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dPreQ0 was found in strains expressing dpdA (ECO_0001096). Phages with modifications (e.g., dG+, dPreQ0, dPreQ1) showed varied resistance to various restriction enzymes.
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MoA Category
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modifies phage molecules to avoid recognition
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Type II RM (in vitro)
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Relevant publication(s)
DOI
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10.1038/s41467-019-13384-y
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Enterobacteria phage 9g
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Defence system(s) inhibited by the protein
Defences
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RM
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