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Mode of Action (MoA)
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None
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Evidence
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gnarl1 (orf48) enhanced infection by phage T5 in multiple E. coli strains where wild-type O-antigen structures normally block phage adsorption. Expression of gnarl1 (ECO_0000017) induced detectable downshifts in O-antigen banding patterns, similar to seroconverting lysogens. These effects were mirrored by host mutants lacking O-antigen biosynthesis genes. Together, these results indicate gnarl1 modifies or downregulates O-antigen to facilitate phage entry.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli O-antigen-based barrier
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Relevant publication(s)
DOI
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10.1101/2023.04.06.535777
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Klebsiella phage vB_KpnM_KpV79
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Defence system(s) inhibited by the protein
Defences
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O-antigen-based barrier
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