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Mode of Action (MoA)
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None
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Evidence
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gnarl3 (orf92) expression led to increased susceptibility to phage T5 and T4 across multiple hosts. AP-MS identified interactions between gnarl3 and host UDP-glucose biosynthesis proteins (ECO_0001096), especially GalU. Overexpression of galU completely suppressed the gnarl3 phenotype, restoring resistance.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli O-antigen-based barrier
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Relevant publication(s)
DOI
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10.1101/2023.04.06.535777
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Escherichia phage Mangalitsa
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Defence system(s) inhibited by the protein
Defences
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O-antigen-based barrier
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