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Mode of Action (MoA)
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inhibits the Lon Protease activity (it degrades the antitoxin)
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Evidence
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Ectopic expression of Gp4.5 in E. coli restored susceptibility to phage in strains otherwise resistant due to the presence of the sanaTA system (ECO_0000017). Co-immunoprecipitation supports direct interaction with the Lon protease (ECO_0006030).
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli type II TA SanaTA
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Relevant publication(s)
DOI
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10.1016/j.molcel.2013.02.002
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Escherichia phage T7
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Defence system(s) inhibited by the protein
Defences
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TA
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