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Mode of Action (MoA)
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None
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Evidence
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A gain-of-function mutants of gp54 (in the DEM 200-series) acquire the ability to bypass the defence (ECO_0000042), but deletion of gp54 (Tweety Δ54) restores sensitivity to the Phrann defence system (ECO_0001038), demonstrating that gp54 is not essential for lytic growth, but its presence (in variant forms) enables escape from prophage-mediated inhibition.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Mycobacterium phage Phrann gp29/gp30
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Relevant publication(s)
DOI
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10.1038/nmicrobiol.2016.251
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Mycobacterium phage Tweety
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Defence system(s) inhibited by the protein
Defences
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gp29/gp30
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