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Mode of Action (MoA)
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None
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Evidence
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Comparative genomics of closely related phages with differential sensitivity to the Hachiman defence system identified Had1 as a factor conferring resistance. Deletion of Had1 from phage SBSphiJ4 (ECO_0001038) rendered it susceptible to Hachiman-mediated defence. Ectopic expression of Had1 in B. subtilis (ECO_0000017) with Hachiman allowed otherwise blocked phages to infect.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Bacillus cereus B4087 Hachiman
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Relevant publication(s)
DOI
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10.1038/s41586-023-06869-w
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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8TTO_A
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Genome(s) encoding the protein
Protein Source
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Bacillus phage SBSphiJ4
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Defence system(s) inhibited by the protein
Defences
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Hachiman
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