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Mode of Action (MoA)
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None
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Evidence
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IpII (orf143) enhanced T2 and T6 phage infectivity in ECOR21, which normally restricts these phages via a fused Type IV R-M enzyme, GmrSD. In a ∆wecA background lacking O-antigen, transposon disruption of the GmrSD locus mimicked the effect of IpII, confirming it as the target. Cloned expression of GmrSD blocked T2, but this restriction was relieved by co-expression of IpII (ECO_0000017).
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli type IV RM
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Relevant publication(s)
DOI
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10.1101/2023.04.06.535777
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Binds and inhibits the gmrS/gmrD complex (glucose-modified hydroxymethylcytosine restriction endonuclease)
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Defence system(s) inhibited by the protein
Defences
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RM
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