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Mode of Action (MoA)
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None
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Evidence
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KlcA expression in E. coli enables infection by phages even in the presence of functional Type I RM systems IA–ID. This confirms robust anti‑restriction activity in living cells. Purified KlcA also doesn’t inhibit EcoKI enzyme activity in vitro.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli type I RM
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Relevant publication(s)
DOI
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10.1093/nar/gkp1144
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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2KMG
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Genome(s) encoding the protein
Protein Source
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Plasmid pBP136
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Defence system(s) inhibited by the protein
Defences
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RM
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