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Mode of Action (MoA)
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None
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Evidence
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Lidtsur-17 was shown to be a potent inhibitor of the Avs3 system. In the same pooled genetic screen with Lidtsur-6 and Forsur-7, Lidtsur-17 was among the most enriched genes, strongly rescuing SeAvs3-induced toxicity in E. coli. In vitro biochemical reconstitution demonstrated that Lidtsur-17 robustly blocked SeAvs3's DNA endonuclease activity in the presence of its trigger protein. In phage plaque assays, Lidtsur-17 restored phage infectivity on strains expressing Avs3, confirming its role in disabling Avs defense in vivo.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Salmonella enterica type III Avs
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Relevant publication(s)
DOI
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10.1126/science.abm4096
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Escherichia phage Lidtsur
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Defence system(s) inhibited by the protein
Defences
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Avs
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