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Mode of Action (MoA)
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None
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Evidence
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Lidtsur-6 also functioned as an Avs inhibitor, albeit with moderate activity. Identified in the genetic suppression screen, it was found to confer partial protection against SeAvs3-mediated toxicity. Its expression in plaque assays restored infectivity of phages on E. coli harboring SeAvs3, suggesting that it inhibits the defense system in vivo. It does not inhibit the defence system in vitro, suggesting a possible indirect or context-dependent mode of action, possibly affecting Avs assembly or activation.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Salmonella enterica type III Avs
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Relevant publication(s)
DOI
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10.1126/science.abm4096
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Escherichia phage Lidtsur
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Defence system(s) inhibited by the protein
Defences
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Avs
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