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Mode of Action (MoA)
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synthesises cyclic dinucleotides that bind to and competitively inhibit host STING immune sensors.
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Evidence
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Mass spectrometry evidence (ECO_0001096) for production of cyclic nucleotide. The NTases inhibited the NADase activity of TIR-STING from Sphingobacterium faecium in a dose-dependent manner, measured using a fluorescent ε-NAD substrate assay (ECO_0000184).
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MoA Category
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uncategorised
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Sphingobacterium faecium TIR-STING effector
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Relevant publication(s)
DOI
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10.1016/j.celrep.2023.112305
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Bacillus phage Bcp1
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Defence system(s) inhibited by the protein
Defences
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CBASS,
CRISPR-Cas
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View homologs from eukaryotic dsDNA viruses
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