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Mode of Action (MoA)
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None
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Evidence
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orf126 was identified as a broad-spectrum counter-defense gene that enhanced phage infectivity in multiple E. coli strains. Its expression (ECO_0000017) increased plaquing efficiency for several phages, indicating suppression of host defenses. Transposon knockout of capsule and O-antigen biosynthesis genes phenocopied orf126 expression, suggesting that orf126 impairs surface barrier defenses. Affinity purification-mass spectrometry (AP-MS) revealed that orf126 shares host binding partners with known anti-defense protein orf116 (abc1), further supporting its counter-defense role (ECO_0001096).
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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None
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Relevant publication(s)
DOI
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10.1101/2023.04.06.535777
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Enterobacteriophages
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Defence system(s) inhibited by the protein
Defences
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Broad-spectrum counter-defense
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