|
Mode of Action (MoA)
|
None
|
|
Evidence
|
orf148 expression conferred increased phage infectivity in diverse E. coli strains (ECO_0000017), independent of variable defense gene repertoires. Like orf126, transposon inactivation of capsule or O-antigen biosynthesis genes mirrored orf148’s effect, suggesting disruption of conserved envelope barriers. These infection phenotypes across multiple hosts and phages indicate orf148 acts as a general anti-barrier defense protein.
|
|
MoA Category
|
unknown
|
|
Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
|
None
|
|
Relevant publication(s)
DOI
|
10.1101/2023.04.06.535777
|
|
Other components of the anti-defence system
Multicomponent System
|
-
|
|
Known structure in PDB
PDB ID
|
-
|
|
Genome(s) encoding the protein
Protein Source
|
Enterobacteriophages
|
|
Defence system(s) inhibited by the protein
Defences
|
Broad-spectrum counter-defense
|