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Mode of Action (MoA)
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None
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Evidence
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In Brex type I-bearing E. coli, ΔORF46 phages exhibited strongly reduced infectivity. Complementation with plasmid-encoded ORF46 fully restored infectivity, confirming its anti-Brex activity.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli type I BREX
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Relevant publication(s)
DOI
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10.1101/2024.04.14.589459
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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DruSM1 phage
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Defence system(s) inhibited by the protein
Defences
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BREX
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