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Mode of Action (MoA)
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predicted to bind ATP and NAD as a dimer. Triggers retron Ec86.
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Evidence
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Deletion of ORF58 reduced infectivity in Sir2+HerA- and DUF4297+HerA-expressing strains, indicating anti-defense roles. Complementation with ORF58 restored infectivity in both systems.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli Sir2+HerA and DUF4297+HerA
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Relevant publication(s)
DOI
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10.1101/2024.04.14.589459
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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DruSM1 phage
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Defence system(s) inhibited by the protein
Defences
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Sir2+HerA,
DUF4297+HerA
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