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Mode of Action (MoA)
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binds to the Lon protease, which degrage some antitoxins
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Evidence
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PinA inhibits ATP-dependent degradation of casein by Lon protease, as measured by the release of trichloroacetic acid-soluble peptides from [³H]-labeled casein. PinA forms a stable complex with Lon, shown by co-elution during gel filtration chromatography (ECO_0001049).
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli RM Lon Protease
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Relevant publication(s)
DOI
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10.1074/jbc.273.1.518
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Enterobacteria phage T4
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Defence system(s) inhibited by the protein
Defences
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TA
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