|
Mode of Action (MoA)
|
Enables bacteriophage λ to utilize the host EcoK methyltransferase to methylate its own genome, thereby enhancing modification and alleviating restriction. Ral likely interacts with the HsdM or HsdS subunits of the EcoK complex, altering their conformation to increase methylation efficiency.
|
|
Evidence
|
Ectopic expression evidence (ECO_0000017)
|
|
MoA Category
|
uncategorised
|
|
Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
|
Escherichia coli type I RM
|
|
Relevant publication(s)
DOI
|
10.1016/0022-2836(86)90071-9
|
|
Other components of the anti-defence system
Multicomponent System
|
-
|
|
Known structure in PDB
PDB ID
|
-
|
|
Genome(s) encoding the protein
Protein Source
|
Phage λreverse
|
|
Defence system(s) inhibited by the protein
Defences
|
RM
|