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Mode of Action (MoA)
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None
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Evidence
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Plasmid-expressed rexA and rexB were sufficient to restrict T4 rII mutants, even in the absence of lambda cI repressor, establishing a direct functional interaction between RIIA and rex products. Growth restriction of wild-type T4 (rIIA⁺, rIIB⁺) by rex was demonstrated in engineered E. coli strains expressing rex genes under strong promoters (e.g., prex20) and was more stringent at higher temperatures. This indicates that RIIA is involved in mitigating rex-induced abortive infection under normal conditions.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli RexAB
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Relevant publication(s)
DOI
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10.1128/jvi.61.12.3790-3794.1987
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Enterobacteria phage T4
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Defence system(s) inhibited by the protein
Defences
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RexAB
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View homologs from eukaryotic dsDNA viruses
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