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Mode of Action (MoA)
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AlphaFold 3 predicts a direct interaction between the helicase Cas3 (https://www.ncbi.nlm.nih.gov/protein/WP_014513746.1) and SIFV2 gp15 (ipTM = 0.79, pTM = 0.81).
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Evidence
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Binding it supported by computational structure modeling evidence (ECO_0006368). Ectopic expression of sifv2_gp15 (ECO_0000017) restores infectivity of susceptible SIRV2MΔgp45–47 in Sulfolobus strain with an active subtype I-A system.
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MoA Category
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binds and inhibits host defence system (putative)
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Sulfolobus islandicus CRISPR-Cas subtype I-A
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Relevant publication(s)
DOI
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10.1038/s41467-024-48074-x
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Sulfolobus islandicus filamentous virus 2
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Defence system(s) inhibited by the protein
Defences
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CRISPR-Cas
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