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Mode of Action (MoA)
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Expression of Stp alleviates the restriction, and it is proposed that it binds to EcoPrrI. It triggers PrrC defence, and both inhibition and activation depend on the same residues within the N-proximal 18-residue region of Stp.
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Evidence
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Ectopic expression evidence supports anti-RM activity (ECO_0000017)
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Escherichia coli type IC RM
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Relevant publication(s)
DOI
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10.1006/jmbi.1995.0343
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Enterobacteria phage T4
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Defence system(s) inhibited by the protein
Defences
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RM
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