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Mode of Action (MoA)
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binds to the bacterial ThsB (Thoeris type I) and also inhibits plant (Brachypodium distachyon, BdTIR) and human (Sterile alpha and TIR motif containing 1, SARM1) TIR proteins involved in the innate immune response.
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Evidence
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Ectopic expression (ECO_0000017) of tad4 in Bacillus cereus inhibits Thoeris-mediated antiphage defense in a plaque formation assay. Binding is supported by co-purification in pull-down assays (co-purification evidence, ECO_0006074).
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MoA Category
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binds and inhibits host defence system
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Bacillus cereus MSX-D12 type I Thoeris
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Relevant publication(s)
DOI
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10.1016/j.cell.2024.12.035
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Other components of the anti-defence system
Multicomponent System
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-
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Ga0307375_1001427612 (IMG/VR)
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Defence system(s) inhibited by the protein
Defences
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Thoeris
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