|
Mode of Action (MoA)
|
binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.
|
|
Evidence
|
Biochemical evidence of inhibition of UDG activity using a [³H]-poly(dU) substrate (ECO_0000184).
|
|
MoA Category
|
binds and inhibits host defence system
|
|
Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
|
Bacillus subtilis uracil-DNA glycosylase
|
|
Relevant publication(s)
DOI
|
10.1016/S0021-9258(19)70472-4
|
|
Other components of the anti-defence system
Multicomponent System
|
-
|
|
Known structure in PDB
PDB ID
|
-
|
|
Genome(s) encoding the protein
Protein Source
|
Bacillus phage PBS2
|
|
Defence system(s) inhibited by the protein
Defences
|
DNA repair
|