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Mode of Action (MoA)
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None
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Evidence
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Deletion of vcrx089-090 (ECO_0007379) led to a 25-fold decrease in conjugation efficiency to V. cholerae O395 (which has an active type I R-M system). The transfer defect was rescued by deleting the recipient’s hsdR gene, confirming it’s R-M-related. Complementation in recipient cells (not donors) restored transfer efficiency, supporting their function post-DNA entry.
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MoA Category
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unknown
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Vibrio cholerae type I CRISPR-Cas
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Relevant publication(s)
DOI
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10.1093/nar/gkaa518
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Other components of the anti-defence system
Multicomponent System
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vcrx089
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Plasmid pVCR94
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Defence system(s) inhibited by the protein
Defences
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RM
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