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Mode of Action (MoA)
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adds a pyrophosphate group from ATP to ADPR to create ADPR-PP
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Evidence
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Expression of Adps homolog from phage SpβL1 produced ADPR-PP from ADPR and ATP in vitro. Mass spectrometry (MS/MS) confirmed the identity of the reaction products (ADPR-PP and ADPR-cyclic phosphate, ECO_0001096). Mutation of a key active site residue (K162A) abolished activity, showing the importance of this residue (ECO_0000015).
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MoA Category
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synthesises and restores essential molecules depleted by bacterial defence
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Subtype(s) of the defence system(s) inhibited by the protein
Defence Subtype
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Bacillus subtilis type I Thoeris, DSR1, DSR2 and SEFIR. Escherichia coli SIR2–HerA
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Relevant publication(s)
DOI
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10.1038/s41586-024-07986-w
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Other components of the anti-defence system
Multicomponent System
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namat
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Known structure in PDB
PDB ID
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-
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Genome(s) encoding the protein
Protein Source
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Escherichia phage JohannRWettstein (Bas63)
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Defence system(s) inhibited by the protein
Defences
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Thoeris,
DSR,
SIR2-HerA,
SEFIR
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