Bacterial virus anti-defence systems · sequence & structure resource

Encyclopaedia of Bacterial Virus Anti-Defence Systems


Protein: RNA_ligase_1

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Overview

Mode of Action (MoA) Ligates the broken ends of tRNA (a 5'-phosphate and 3'-OH).
Evidence Enzymatic activity assay evidence supports ligase activity (ECO_0000005).
MoA Category synthesises and restores essential molecules depleted by bacterial defence
Subtype(s) of the defence system(s) inhibited by the protein Defence Subtype Escherichia coli PrrC
Relevant publication(s) DOI 10.1002/j.1460-2075.1987.tb02532.x
Other components of the anti-defence system Multicomponent System pnk
Known structure in PDB PDB ID 5TT6
Genome(s) encoding the protein Protein Source Enterobacteria phage T4
Defence system(s) inhibited by the protein Defences PrrC
View homologs from eukaryotic dsDNA viruses

3D structure

PDB entry model.

A similar PDB structure exists: 5TT6

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Feature viewer - predicted secondary structure

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Pfam annotations

Pfam Name Pfam Acc Pfam Length Colour HMM Start HMM End Ali Start Ali End Env Start Env End Evalue
RNA_lig_T4_1 PF09511 227 1 227 52 246 52 246 5.8e-27
T4_Rnl1_C PF20819 122 1 122 253 374 253 374 1.9e-41

Sequence Viewer

Amino acid position: -

MQELFNNLMELCKDSQRKFFYSDDVSASGRTYRIFSYNYASYSDWLLPDALECRGIMFEMDGEKPVRIASRPMEKFFNLNENPFTMNIDLNDVDYILTKEDGSLVSTYLDGDEILFKSKGSIKSEQALMANGILMNINHHRLRDRLKELAEDGFTANFEFVAPTNRIVLAYQEMKIILLNVRENETGEYISYDDIYKDATLRPYLVERYEIDSPKWIEEAKNAENIEGYVAVMKDGSHFKIKSDWYVSLHSTKSSLDNPEKLFKTIIDGASDDLKAMYADDEYSYRKIEAFETTYLKYLDRALFLVLDCHNKHCGKDRKTYAMEAQGVAKGAGMDHLFGIIMSLYQGYDSQEKVMCEIEQNFLKNYKKFIPEGY