Bacterial virus anti-defence systems · sequence & structure resource

Encyclopaedia of Bacterial Virus Anti-Defence Systems


Protein: Hdf

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Overview

Mode of Action (MoA) binds and protects phage DNA.
Evidence Genetic deletions (deletion mutation phenotypic evidence, ECO_0001038) result in high sensitivity to RM systems, while ectopic expression (ECO_0000017) restores plating efficiency.
MoA Category binds and protects the component targeted by the host defence
Subtype(s) of the defence system(s) inhibited by the protein Defence Subtype Escherichia coli type I RM
Relevant publication(s) DOI 10.1016/0042-6822(87)90324-2, 10.1111/mmi.13705
Other components of the anti-defence system Multicomponent System dara; ddrb; darb; ddra; ulx
Known structure in PDB PDB ID -
Genome(s) encoding the protein Protein Source Enterobacteria phage P1
Defence system(s) inhibited by the protein Defences RM

3D structure

AlphaFold 3 model.

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Feature viewer - predicted secondary structure

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Pfam annotations

Pfam Name Pfam Acc Pfam Length Colour HMM Start HMM End Ali Start Ali End Env Start Env End Evalue
DarA_N PF18788 122 2 122 13 109 12 109 3.2e-24

Sequence Viewer

Amino acid position: -

MCQMTKNKYATVDFDQVNEKGLKSLITAINKTGVTVIEVDSSNRATTKDGVKVKTAKLVLSDGQILAIQVNDTGDISSVKLNGKAIPNAQSPDIKTLGTVMGQAARKNSAKFQKSLIAKAKRVANPVDKKPAVKSNFQRLQEAKQRNAQVVAAYKSAQNSVSFNQQQITDLRAKLDKETGRLNNEKARNGELKRRLKQLKAGN